BMAC Reduces Pain 70% in Moderate-Advanced OA Intra-articular bone marrow concentrate injection protocol: short-term efficacy in osteoarthritis 125 patients received a BMAC injection and a PRP injection 8 weeks after. Median absolute pain reduction in all joints was five points (71.4%) on visual analog scale. Median patient satisfaction was 9.0/10, while 91.7% indicated that they would repeat the procedure and 94% said that they would recommend the procedure to a friend

BMAC Review Article Hematopoietic and Mesenchymal Stem Cells in Biomedical and Clinical Applications: 2016

BMAC Helps Moderate-Advanced Knee OA Effectiveness of a single intra-articular bone marrow aspirate concentrate (BMAC) injection in patients with grade 3 and 4 knee osteoarthritis 2018.  There were 85 females and 36 males, with mean age 70 years (range 50–85).  A single intra-articular injection of BMAC is a safe and reliable procedure that results in clinical improvement of knee OA.

BMAC helps Knee and Hip OA The safety and effectiveness of bone marrow concentrate injection for knee and hip osteoarthritis: a Canadian cohort 2021 Outcome scores were significantly improved at all time points post-BMC injection with maximal improvement observed at 3–6 months. Improvements were unrelated to patient age, sex or radiographic OA severity. The complication rate was <2%.

BMAC was better then HA or ACS Bone Marrow Aspirate Concentrate Is More Effective Than Hyaluronic Acid and Autologous Conditioned Serum in the Treatment of Knee Osteoarthritis: A Retrospective Study of 505 Consecutive Patients 2021  At 12 months, VAS was improved in all three treatment groups, yet only BMAC sustained the improved WOMAC even in patients with more severe degenerative changes. This study shows that BMAC is more effective than HA and ACS in the treatment of symptomatic knee OA, especially in the patients with more severe degenerative changes

Stem Cells and Knee Osteoarthritis: Orozco et al 2013 -Patients exhibited rapid and progressive improvement of pain and function approaching 65% to 78% by 1 year. Additionally 11 of 12 patients had improvement in cartilage scores as seen on MRI.

BMAC Improved Moderate Knee OA > 75% Short Term Clinical Results of Single Injection Autologous BMAC (Bone Marrow Aspirate Concentrate) As A Therapeutic Option/Tool in Knee Osteoarthritis 2021

In all 132 patients, improvement of pain was observed as early as at the end of the 3rd month following BMAC injection to an extent of 75% compared to pre injection by VAS and steadily improved to almost complete relief of pain by the end of the 6th months.

Stem Cell Safety in Osteoarthritis: Emadedin et al 2015 -There was no evidence of tumor or neoplastic changes in the patients during the 30-month follow-up period. All patients exhibited therapeutic benefits such as increased walking distance, decreased visual analog pain scale (VAS), and total Western Ontario and McMaster Universities OA Index (WOMAC) scores which were confirmed by MRI.

Stem Cell Safety and Long Term Follow Up: Wakitani et al. 2011 -Patients often are concerned about the potential risk of growing tumors after their stem cell procedures. At this time there are no reports of ever developing cancer from injections of stem cells into joints. In this study, patients who received stem cell treatments for osteoarthritis were followed for more then 10 years and no tumors or infections were found. The authors concluded “Autologous BMSC transplantation is a safe procedure and will be widely used around the world.”

Stem Cells in Rabbits with Osteoarthritis: Singh et al 2014 -Rabbits receiving stem cells showed a lower degree of cartilage degeneration, osteophyte formation, and subchondral sclerosis than the control group at 20 weeks post-operatively. The quality of cartilage was significantly better in the cell-treated group compared with the control group after 20 weeks.

Stem Cells “Home” to Areas of Arthritis and Repair It:  Mokbel et al 2011 -23 donkeys had arthritis induced in their joints by injection of a chemical. Stem cells were taken from their bones and attached to fluorescent proteins. This was then injected with hyaluronic acid in the joint on one side and the plain hyaluronic acid was injected in the opposite side without stem cells. Both on clinical exam and imaging the joints treated with stem cells showed healing of the cartilage. On biopsy, the fluorescently tagged proteins were also found in the surface and the inside of the joint cartilage proving that stem cells are attracted to areas of injury from arthritis and also repair those areas.

Stem Cells Heal Arthritis in Animal Model: Jiang et al 2014 -Monkeys had osteoarthritis induced in their joints by a chemical injection that harmed the cartilage. Then stem cells were harvested from the monkeys and either salt water or stem cells were injected into the monkey’s joints. Upon clinical and radiologic examination the monkeys who received stem cell injections showed the arthritis was significantly improved and repaired by the stem cell injections but not the salt water.

Stem Cells better than Hyaluronic Acid Injections : Vega et al 2015 -Patients with knee arthritis were randomized to either a single stem cell injection or hyaluronic acid injection to the knee. They were then followed for one year. Patients after the stem cell showed greater improvements in knee function, pain and activity and on MRI showed the quality of their cartilage improved.